Delirium has been previously described as a syndrome of organ dysfunction involving the central nervous system. The prevalence of delirium in the ICU varies from 20-80%. Delirium has been associated with increased hospital length of stay, duration of mechanical ventilation, and mortality. Sedative and narcotic use has been shown to increase the risk and severity of delirium. Haloperidol is the mainstay of delirium management as recommended by the Society of Critical Care Medicine (SCCM) due to extensive clinical experience with this medication. However, its usage is often limited by safety concerns. Atypical antipsychotics such as quetiapine have been shown to have equivalent success in the treatment of delirium while being associated with fewer side effects.